The best time to take Cenforce 100 (sildenafil citrate) is about 30 to 60 minutes before planned sexual activity. This allows the medication enough time to be absorbed and become effective. While it can be taken with or without food, taking it on an empty stomach enhances absorption and speed of action. Cenforce works best when you are sexually stimulated, so timing it with intimacy is key. It remains effective for up to 4–6 hours. There's no specific "time of day" required, but avoiding heavy meals and alcohol around the time of dosing can improve its performance and reduce the risk of side effects.